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Cajun Crispy Chicken Sandwich with Garlic Aioli

This Easy Cajun Crispy Chicken Sandwich with Garlic Aioli is the ultimate homemade takeout fakeout! Perfectly spiced, extra crispy chicken breast, creamy zesty garlic aioli, crisp lettuce, and ripe tomato come together on a soft brioche bun for a sandwich that absolutely crushes the drive-thru competition. For another incredible homemade favorite, try our Firecracker Chicken.
Prep Time15 minutes
Cook Time15 minutes
Marinating Time1 hour
Total Time30 minutes
Course: Lunch, Main Course, Sandwich
Cuisine: American, Cajun-Inspired
Keyword: cajun crispy chicken sandwich, crispy chicken sandwich with aioli, homemade chicken sandwich
Servings: 2 sandwiches
Calories: 650kcal
Author: Angela

Equipment

  • Deep Skillet or Cast Iron Skillet For frying chicken to golden perfection.
  • Oil Thermometer Essential for maintaining the correct 350°F frying temperature.
  • Wire Rack Keeps fried chicken crispy by allowing air circulation underneath.

Ingredients

  • 2 boneless, skinless chicken breasts
  • 1 cup buttermilk
  • 1 tbsp Cajun seasoning (plus more for flour)
  • 1 cup all-purpose flour
  • 1 tsp paprika
  • 1 tsp garlic powder
  • 1 tsp onion powder
  • 0.5 tsp salt
  • 0.5 tsp black pepper
  • Vegetable oil, for frying
  • 0.5 cup mayonnaise
  • 2 cloves garlic, minced
  • 1 tbsp lemon juice
  • 0.5 tsp salt
  • 0.25 tsp black pepper
  • 2 brioche buns, split and toasted
  • Romaine lettuce leaves
  • Ripe tomato, sliced

Instructions

  • In a bowl, combine buttermilk and 1 tbsp Cajun seasoning. Add chicken, cover, and refrigerate for at least 1 hour (or overnight).
  • In a shallow dish, whisk flour, paprika, garlic powder, onion powder, salt, pepper, and extra Cajun seasoning.
  • Heat 2 inches of oil in a deep skillet to 350°F. Remove chicken from buttermilk, dredge in flour mixture, pressing firmly. Fry for 5-7 mins per side until golden and 165°F internally. Drain on a wire rack.
  • In a small bowl, whisk together mayonnaise, minced garlic, lemon juice, salt, and pepper until smooth.
  • Spread aioli on toasted brioche buns. Layer with lettuce, tomato, and crispy chicken. Top with bun and serve immediately.

Notes

Pro Tips: The buttermilk marinade is non-negotiable—it tenderizes the chicken and helps the coating adhere. Marinate for at least 1 hour, or overnight. Maintain oil temperature at 350°F for a perfectly crisp, non-greasy crust. For the crispiest result, drain fried chicken on a wire rack, not paper towels, to prevent steam from softening the crust. Let the dredged chicken rest for 10-15 minutes before frying for an even crunchier coating. Toast your brioche buns for the perfect texture contrast.